Drug target validation: Lethal infection blocked by inducible peptide

Genome projects are generating large numbers of potential new targets for drug discovery. One challenge is target validation, proving the usefulness of a specific target in an animal model. In this paper, we demonstrate a new approach to validation and assay development. We selected in vitro specifi...

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Autori principali: Tao, Jianshi, Wendler, Philip, Connelly, Gene, Lim, Audrey, Zhang, Jiansu, King, Megan, Li, Tongchuan, Silverman, Jared A., Schimmel, Paul R., Tally, Francis P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2000
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC15408/
https://ncbi.nlm.nih.gov/pubmed/10639157
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