A Novel Genetic Pathway of Human Immunodeficiency Virus Type 1 Resistance to Stavudine Mediated by the K65R Mutation

Stavudine (d4T) and zidovudine (AZT) are thymidine analogs widely used in the treatment of human immunodeficiency virus type 1 (HIV-1)-infected persons. Resistance to d4T is not fully understood, although the selection of AZT resistance mutations in patients treated with d4T suggests that both drugs...

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Detalhes bibliográficos
Main Authors: García-Lerma, J. Gerardo, MacInnes, Hamish, Bennett, Diane, Reid, Patrick, Nidtha, Soumya, Weinstock, Hillard, Kaplan, Jonathan E., Heneine, Walid
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC154026/
https://ncbi.nlm.nih.gov/pubmed/12719561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.10.5685-5693.2003
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