IL-18 regulates IL-1β-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1

Proinflammatory cytokines, including IL-1β and tumor necrosis factor-α (TNF-α), promote cancer cell adhesion and liver metastases by up-regulating the expression of vascular cell adhesion molecule-1 (VCAM-1) on hepatic sinusoidal endothelium (HSE). In this study, hepatic metastasis after intraspleni...

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Main Authors: Vidal-Vanaclocha, Fernando, Fantuzzi, Giamila, Mendoza, Lorea, Fuentes, Angela M., Anasagasti, Miren J., Martín, Javier, Carrascal, Teresa, Walsh, Patrick, Reznikov, Leonid L., Kim, Soo-Hyun, Novick, Daniela, Rubinstein, Menachem, Dinarello, Charles A.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC15399/
https://ncbi.nlm.nih.gov/pubmed/10639148
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