Outer Membrane Protein Changes and Efflux Pump Expression Together May Confer Resistance to Ertapenem in Enterobacter cloacae

We investigated ertapenem-susceptible and -resistant extended-spectrum β-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem i...

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Main Authors: Szabó, Dóra, Silveira, Fernanda, Hujer, Andrea M., Bonomo, Robert A., Hujer, Kristine M., Marsh, Jane W., Bethel, Christopher R., Doi, Yohei, Deeley, Kathleen, Paterson, David L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1538668/
https://ncbi.nlm.nih.gov/pubmed/16870780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01591-05
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