The tRNA Primer Activation Signal in the Human Immunodeficiency Virus Type 1 Genome Is Important for Initiation and Processive Elongation of Reverse Transcription

Human immunodeficiency virus type 1 (HIV-1) reverse transcription is primed by the cellular tRNA(3)(Lys) molecule, which binds, with its 3"-terminal 18 nucleotides (nt), to a complementary sequence in the viral genome, the primer-binding site (PBS). Besides PBS-anti-PBS pairing, additional inte...

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Bibliographic Details
Main Authors: Beerens, Nancy, Berkhout, Ben
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC153804/
https://ncbi.nlm.nih.gov/pubmed/11836411
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