Impact of DNA ligase IV on the fidelity of end joining in human cells

A DNA ligase IV (LIG4)-null human pre-B cell line and human cell lines with hypomorphic mutations in LIG4 are significantly impaired in the frequency and fidelity of end joining using an in vivo plasmid assay. Analysis of the null line demonstrates the existence of an error-prone DNA ligase IV-indep...

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Main Authors: Smith, Julianne, Riballo, Enriqueta, Kysela, Boris, Baldeyron, Celine, Manolis, Kostas, Masson, Christel, Lieber, Michael R., Papadopoulo, Dora, Jeggo, Penny
Format: Artigo
Language:Inglês
Published: Oxford University Press 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC153745/
https://ncbi.nlm.nih.gov/pubmed/12682366
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