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The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium

Calpains (calcium-dependent cytoplasmic cysteine proteinases) are implicated in processes such as cytoskeleton remodeling and signal transduction. The 2.3-Å crystal structure of full-length heterodimeric [80-kDa (dI-dIV) + 30-kDa (dV+dVI)] human m-calpain crystallized in the absence of calcium revea...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Strobl, Stefan, Fernandez-Catalan, Carlos, Braun, Marianne, Huber, Robert, Masumoto, Hajime, Nakagawa, Kazuhiro, Irie, Akihiro, Sorimachi, Hiroyuki, Bourenkow, Gleb, Bartunik, Hans, Suzuki, Koichi, Bode, Wolfram
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15374/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10639123/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.2.588
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