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Ensemble and single-molecule fluorescence spectroscopic study of the binding modes of the bis-benzimidazole derivative Hoechst 33258 with DNA

Ensemble and single-molecule fluorescence measurements of 2′-(4-hydroxyphenyl)-5-[5-(4-methylpiperazine-1-yl) benzimidazo-2-yl]-benzimidazole (H-258)– calf thymus (CT) DNA complexes at various [H-258]/[DNA bp] ratios were performed to elucidate the binding of H-258 with DNA. Upon binding to double-s...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Adhikary, Amitava, Buschmann, Volker, Müller, Christian, Sauer, Markus
Format: Artigo
Language:Inglês
Published: Oxford University Press 2003
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153736/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12682368/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg308
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