Formation of the P1.1 pseudoknot is critical for both the cleavage activity and substrate specificity of an antigenomic trans-acting hepatitis delta ribozyme

Hepatitis delta virus RNAs possess self-cleavage activities that produce 2′,3′-cyclic phosphate and 5′-hydroxyl termini (i.e. cis-acting delta ribozyme). Trans-acting delta ribozymes have been engineered by removing a junction from the cis version, thereby producing one molecule possessing the subst...

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Библиографические подробности

Опубликовано в::	Nucleic Acids Res
Главные авторы:	Deschênes, Patrick, Ouellet, Jonathan, Perreault, Jonathan, Perreault, Jean-Pierre
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Oxford University Press 2003
Предметы:	Articles
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153735/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12682359/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg307
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