Bioinformatic design of A-kinase anchoring protein-in silico: A potent and selective peptide antagonist of type II protein kinase A anchoring

Compartmentalization of the cAMP-dependent protein kinase (PKA) is coordinated through association with A-kinase anchoring proteins (AKAPs). A defining characteristic of most AKAPs is a 14- to 18-aa sequence that binds to the regulatory subunits (RI or RII) of the kinase. Cellular delivery of peptid...

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Bibliographic Details
Main Authors: Alto, Neal M., Soderling, Scott H., Hoshi, Naoto, Langeberg, Lorene K., Fayos, Rosa, Jennings, Patricia A., Scott, John D.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC153575/
https://ncbi.nlm.nih.gov/pubmed/12672969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0330734100
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