Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus

BACKGROUND: Insulin dependent (i.e., "type 1") diabetes mellitus (T1DM) is considered to be a T cell mediated disease in which T(H)1 and T(c )autoreactive cells attack the pancreatic islets. Among the beta-cell antigens implicated in T1DM, glutamic acid decarboxylase (GAD) 65 appears to pl...

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Bibliographic Details
Main Authors: Pedotti, Rosetta, Sanna, Maija, Tsai, Mindy, DeVoss, Jason, Steinman, Lawrence, McDevitt, Hugh, Galli, Stephen J
Format: Artigo
Language:Inglês
Published: BioMed Central 2003
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC153530/
https://ncbi.nlm.nih.gov/pubmed/12597780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-4-2
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