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Peptide inhibitors of C3 breakdown.

We have investigated the development of substrate-based inhibitors of complement enzymes. Sequences around the scissile Arg77-Ser78 bond of C3 have been synthesized and tested as inhibitors of C3 convertase. The best inhibition was found with the tetrapeptide Ac-Arg-Ser-Asn-Leu-OH (H-576); extending...

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Detalhes bibliográficos
Main Authors: Peake, P, Szelke, M, Jones, D M, Singleton, A, Sueiras-Diaz, J, Lachmann, P J
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1534956/
https://ncbi.nlm.nih.gov/pubmed/2138528
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