Cyclo-oxygenase-2 (Cox-2) expression and resistance to platinum versus platinum/paclitaxel containing chemotherapy in advanced ovarian cancer

BACKGROUND: Cyclo-oxygenase-2 (COX-2), the key enzyme in the conversion of arachidonic acid to prostaglandins, is involved in critical steps of tumor onset and progression, and is a strong predictor of chemotherapy resistance and poor outcome in advanced ovarian cancer. To our knowledge, no data has...

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Detalhes bibliográficos
Main Authors: Ferrandina, Gabriella, Ranelletti, Franco O, Martinelli, Enrica, Paglia, Amelia, Zannoni, Gian Franco, Scambia, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1534059/
https://ncbi.nlm.nih.gov/pubmed/16831230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-6-182
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