Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort

BACKGROUND: Pathological brain iron deposition has been implicated as a source of neurotoxic reactive oxygen species in Alzheimer (AD) and Parkinson diseases (PD). Iron metabolism is associated with the gene hemochromatosis (HFE Human genome nomenclature committee ID:4886), and mutations in HFE are...

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Detalhes bibliográficos
Main Authors: Guerreiro, Rita J, Bras, Jose M, Santana, Isabel, Januario, Cristina, Santiago, Beatriz, Morgadinho, Ana S, Ribeiro, Maria H, Hardy, John, Singleton, Andrew, Oliveira, Catarina
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1534050/
https://ncbi.nlm.nih.gov/pubmed/16824219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2377-6-24
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