Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G(1) arrest after γ-irradiation

In mammalian cells, activation of certain checkpoint pathways as a result of exposure to genotoxic agents results in cell cycle arrest. The integrity of these arrest pathways is critical to the ability of the cell to repair mutations that otherwise might compromise viability or contribute to deregul...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Brugarolas, James, Moberg, Ken, Boyd, Scott D., Taya, Yoichi, Jacks, Tyler, Lees, Jacqueline A.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1999
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15340/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9927683/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.3.1002
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