Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block

The role of cardiocytes in physiologic removal of apoptotic cells and the subsequent effect of surface binding by anti-SSA/Ro and -SSB/La antibodies was addressed. Initial experiments evaluated induction of apoptosis by extrinsic and intrinsic pathways. Nuclear injury and the translocation of SSA/Ro...

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Main Authors: Clancy, Robert M., Neufing, Petra J., Zheng, Ping, O’Mahony, Marguerita, Nimmerjahn, Falk, Gordon, Tom P., Buyon, Jill P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2006
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1533875/
https://ncbi.nlm.nih.gov/pubmed/16906225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27803
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