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Inactivation of the srtA Gene Affects Localization of Surface Proteins and Decreases Adhesion of Streptococcus pneumoniae to Human Pharyngeal Cells In Vitro

Inactivation of sortase gene srtA in Streptococcus pneumoniae strain R6 caused the release of β-galactosidase and neuraminidase A (NanA) from the cell wall into the surrounding medium. Both of these surface proteins contain the LPXTG motif in the C-terminal domain. Complementation with plasmid-borne...

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Autors principals: Kharat, Arun S., Tomasz, Alexander
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC153252/
https://ncbi.nlm.nih.gov/pubmed/12704150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.5.2758-2765.2003
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