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Human MPS1 Kinase Is Required for Mitotic Arrest Induced by the Loss of CENP-E from Kinetochores

We have determined that the previously identified dual-specificity protein kinase TTK is the human orthologue of the yeast MPS1 kinase. Yeast MPS1 (monopolar spindle) is required for spindle pole duplication and the spindle checkpoint. Consistent with the recently identified vertebrate MPS1 homologu...

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Autors principals: Liu, Song-Tao, Chan, Gordon K.T., Hittle, James C., Fujii, Gregory, Lees, Emma, Yen, Tim J.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC153128/
https://ncbi.nlm.nih.gov/pubmed/12686615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.02-05-0074
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