Origins of DNA-binding specificity: Role of protein contacts with the DNA backbone

A central question in protein–DNA recognition is the origin of the specificity that permits binding to the correct site in the presence of excess, nonspecific DNA. In the P22 Arc repressor, the Phe-10 side chain is part of the hydrophobic core of the free protein but rotates out to pack against the...

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izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Schildbach, Joel F., Karzai, A. Wali, Raumann, Brigitte E., Sauer, Robert T.
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1999
Teme:	Biological Sciences
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15307/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9927650/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.3.811
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