Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis

Clonal expansions of CD8+ T cells have been identified in muscle and blood of polymyositis patients by PCR techniques, including T cell receptor (TCR) complementarity-determining region (CDR)3 length analysis (spectratyping). To examine a possible pathogenic role of these clonally expanded T cells,...

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Main Authors: Hofbauer, Monika, Wiesener, Solveigh, Babbe, Holger, Roers, Axel, Wekerle, Hartmut, Dornmair, Klaus, Hohlfeld, Reinhard, Goebels, Norbert
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC153053/
https://ncbi.nlm.nih.gov/pubmed/12651958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0236183100
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