Structural effects of quinacrine binding in the open channel of the acetylcholine receptor
Noncompetitive inhibitors of the nicotinic acetylcholine (ACh) receptors suppress cation flux directly by binding in and blocking the open channel or indirectly by stabilizing closed states of the receptor. The lidocaine derivative QX-314 and the acridine derivative quinacrine act directly as open c...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2003
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153021/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12644710/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0730718100 |
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