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Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome

Hemolytic uremic syndrome (HUS) is a disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Recent studies have identified a factor H–associated form of HUS, caused by gene mutations that cluster in the C-terminal region of the complement regulator fac...

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Udgivet i:J Clin Invest
Principais autores: Manuelian, Tamara, Hellwage, Jens, Meri, Seppo, Caprioli, Jessica, Noris, Marina, Heinen, Stefan, Jozsi, Mihaly, Neumann, Hartmut P.H., Remuzzi, Giuseppe, Zipfel, Peter F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2003
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152934/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12697737/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI16651
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