CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4(+) T lymphocytes

Azathioprine and its metabolite 6-mercaptopurine (6-MP) are immunosuppressive drugs that are used in organ transplantation and autoimmune and chronic inflammatory diseases such as Crohn disease. However, their molecular mechanism of action is unknown. In the present study, we have identified a uniqu...

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Main Authors: Tiede, Imke, Fritz, Gerhard, Strand, Susanne, Poppe, Daniela, Dvorsky, Radovan, Strand, Dennis, Lehr, Hans Anton, Wirtz, Stefan, Becker, Christoph, Atreya, Raja, Mudter, Jonas, Hildner, Kai, Bartsch, Brigitte, Holtmann, Martin, Blumberg, Richard, Walczak, Henning, Iven, Heiko, Galle, Peter R., Ahmadian, Mohammad Reza, Neurath, Markus F.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2003
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC152932/
https://ncbi.nlm.nih.gov/pubmed/12697733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316432
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