CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4(+) T lymphocytes

Azathioprine and its metabolite 6-mercaptopurine (6-MP) are immunosuppressive drugs that are used in organ transplantation and autoimmune and chronic inflammatory diseases such as Crohn disease. However, their molecular mechanism of action is unknown. In the present study, we have identified a uniqu...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tiede, Imke, Fritz, Gerhard, Strand, Susanne, Poppe, Daniela, Dvorsky, Radovan, Strand, Dennis, Lehr, Hans Anton, Wirtz, Stefan, Becker, Christoph, Atreya, Raja, Mudter, Jonas, Hildner, Kai, Bartsch, Brigitte, Holtmann, Martin, Blumberg, Richard, Walczak, Henning, Iven, Heiko, Galle, Peter R., Ahmadian, Mohammad Reza, Neurath, Markus F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2003
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC152932/
https://ncbi.nlm.nih.gov/pubmed/12697733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316432
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg