Sensitizing antigen-specific CD8(+) T cells for accelerated suicide causes immune incompetence

Death receptor–mediated activation-induced apoptosis of antigen-specific T cells is a major mechanism of peripheral tolerance induction and immune homeostasis. Failure to undergo activation-induced cell death (AICD) is an important underlying cause of many autoimmune diseases. Thus, enhancing the T...

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Detalhes bibliográficos
Main Authors: Wasem, Christoph, Arnold, Diana, Saurer, Leslie, Corazza, Nadia, Jakob, Sabine, Herren, Simon, Vallan, Claudio, Mueller, Christoph, Brunner, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC152931/
https://ncbi.nlm.nih.gov/pubmed/12697738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316344
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