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Sensitizing antigen-specific CD8(+) T cells for accelerated suicide causes immune incompetence
Death receptor–mediated activation-induced apoptosis of antigen-specific T cells is a major mechanism of peripheral tolerance induction and immune homeostasis. Failure to undergo activation-induced cell death (AICD) is an important underlying cause of many autoimmune diseases. Thus, enhancing the T...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC152931/ https://ncbi.nlm.nih.gov/pubmed/12697738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316344 |
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