ICP27 interacts with SRPK1 to mediate HSV splicing inhibition by altering SR protein phosphorylation

Infection with some viruses can alter cellular mRNA processing to favor viral gene expression. We present evidence that herpes simplex virus 1 (HSV-1) protein ICP27, which contributes to host shut-off by inhibiting pre-mRNA splicing, interacts with essential splicing factors termed SR proteins and a...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Sciabica, Kathryn S., Dai, Qian J., Sandri-Goldin, Rozanne M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2003
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152910/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12660167/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg166
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