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Analyzing partially randomized nucleic acid pools: straight dope on doping

Partially randomized (doped) pools are important for optimizing activities initially isolated by selection-amplification or SELEX, and for locating nucleotides critical for function. Here we present a method for calculating the number of unique sequences in a pool, and the expected copy number of ea...

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Publicat a:Nucleic Acids Res
Autors principals: Knight, Rob, Yarus, Michael
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2003
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152884/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12626729/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gng030
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