Rapid Evolution of Major Histocompatibility Complex Class I Genes in Primates Generates New Disease Alleles in Humans via Hitchhiking Diversity

A plausible explanation for many MHC-linked diseases is lacking. Sequencing of the MHC class I region (coding units or full contigs) in several human and nonhuman primate haplotypes allowed an analysis of single nucleotide variations (SNV) across this entire segment. This diversity was not evenly di...

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Autors principals: Shiina, Takashi, Ota, Masao, Shimizu, Sayoko, Katsuyama, Yoshihiko, Hashimoto, Nami, Takasu, Miwa, Anzai, Tatsuya, Kulski, Jerzy K., Kikkawa, Eri, Naruse, Taeko, Kimura, Natsuki, Yanagiya, Kazuyo, Watanabe, Atsushi, Hosomichi, Kazuyoshi, Kohara, Sakae, Iwamoto, Chie, Umehara, Yumi, Meyer, Alice, Wanner, Valérie, Sano, Kazumi, Macquin, Cécile, Ikeo, Kazuho, Tokunaga, Katsushi, Gojobori, Takashi, Inoko, Hidetoshi, Bahram, Seiamak
Format: Artigo
Idioma:Inglês
Publicat: Copyright © 2006 by the Genetics Society of America 2006
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Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1526686/
https://ncbi.nlm.nih.gov/pubmed/16702430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.057034
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