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The TGF-β1/Upstream Stimulatory Factor-Regulated PAI-1 Gene: Potential Involvement and a Therapeutic Target in Alzheimer's Disease
Amyloid peptide (Aβ) aggregates, derived from initial β-site proteolytic processing of the amyloid precursor protein (APP), accumulate in the brains of Alzheimer's disease patients. The plasmin-generating cascade appears to serve a protective role in the central nervous system since plasmin-med...
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| Natura: | Artigo |
| Lingua: | Inglês |
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Hindawi Publishing Corporation
2006
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1526650/ https://ncbi.nlm.nih.gov/pubmed/17047299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/JBB/2006/15792 |
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