Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site

A major and early feature of cartilage degeneration is proteoglycan breakdown. Matrix metalloprotease (MMP)-13 plays an important role in cartilage degradation in osteoarthritis (OA). This MMP, in addition to initiating collagen fibre cleavage, acts on several proteoglycans. One of the proteoglycan...

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Detalhes bibliográficos
Main Authors: Monfort, Jordi, Tardif, Ginette, Reboul, Pascal, Mineau, François, Roughley, Peter, Pelletier, Jean-Pierre, Martel-Pelletier, Johanne
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1526547/
https://ncbi.nlm.nih.gov/pubmed/16507124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1873
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