Crosslinks Rather Than Strand Breaks Determine Access to Ancient DNA Sequences From Frozen Sediments

Diagenesis was studied in DNA obtained from Siberian permafrost (permanently frozen soil) ranging from 10,000 to 400,000 years in age. Despite optimal preservation conditions, we found the sedimentary DNA to be severely modified by interstrand crosslinks; single- and double-stranded breaks; and free...

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Detalhes bibliográficos
Principais autores: Hansen, Anders J., Mitchell, David L., Wiuf, Carsten, Paniker, Lakshmi, Brand, Tina B., Binladen, Jonas, Gilichinsky, David A., Rønn, Regin, Willerslev, Eske
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright © 2006 by the Genetics Society of America 2006
Assuntos:
Letter to the Editor
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1526502/
https://ncbi.nlm.nih.gov/pubmed/16582426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.057349
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