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A Defect in Protein Farnesylation Suppresses a Loss of Schizosaccharomyces pombe tsc2(+), a Homolog of the Human Gene Predisposing to Tuberous Sclerosis Complex
Mutations in the human Tsc1 and Tsc2 genes predispose to tuberous sclerosis complex (TSC), a disorder characterized by the wide spread of benign tumors. Tsc1 and Tsc2 proteins form a complex and serve as a GTPase-activating protein (GAP) for Rheb, a GTPase regulating a downstream kinase, mTOR. The g...
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| Główni autorzy: | , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Copyright © 2006 by the Genetics Society of America
2006
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1526497/ https://ncbi.nlm.nih.gov/pubmed/16624901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.056895 |
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