A Defect in Protein Farnesylation Suppresses a Loss of Schizosaccharomyces pombe tsc2(+), a Homolog of the Human Gene Predisposing to Tuberous Sclerosis Complex

Mutations in the human Tsc1 and Tsc2 genes predispose to tuberous sclerosis complex (TSC), a disorder characterized by the wide spread of benign tumors. Tsc1 and Tsc2 proteins form a complex and serve as a GTPase-activating protein (GAP) for Rheb, a GTPase regulating a downstream kinase, mTOR. The g...

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Main Authors: Nakase, Yukiko, Fukuda, Keiko, Chikashige, Yuji, Tsutsumi, Chihiro, Morita, Daisuke, Kawamoto, Shinpei, Ohnuki, Mari, Hiraoka, Yasushi, Matsumoto, Tomohiro
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright © 2006 by the Genetics Society of America 2006
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Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1526497/
https://ncbi.nlm.nih.gov/pubmed/16624901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.056895
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