Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis

Endothelial cell production of anticoagulant heparan sulfate (HS(act)) is controlled by the Hs3st1 gene, which encodes the rate-limiting enzyme heparan sulfate 3-O-sulfotransferase-1 (3-OST-1). In vitro, HS(act) dramatically enhances the neutralization of coagulation proteases by antithrombin. The i...

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Detalhes bibliográficos
Main Authors: HajMohammadi, Sassan, Enjyoji, Keiichi, Princivalle, Marc, Christi, Patricia, Lech, Miroslav, Beeler, David, Rayburn, Helen, Schwartz, John J., Barzegar, Samad, de Agostini, Ariane I., Post, Mark J., Rosenberg, Robert D., Shworak, Nicholas W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC152578/
https://ncbi.nlm.nih.gov/pubmed/12671048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200315809
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