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A Unique Autophosphorylation Site on Tie2/Tek Mediates Dok-R Phosphotyrosine Binding Domain Binding and Function

Tie2/Tek is an endothelial cell receptor tyrosine kinase that induces signal transduction pathways involved in cell migration upon angiopoietin-1 (Ang1) stimulation. To address the importance of the various tyrosine residues of Tie2 in signal transduction, we generated a series of Tie2 mutants and e...

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Hlavní autoři: Jones, Nina, Chen, Stephen H., Sturk, Celina, Master, Zubin, Tran, Jennifer, Kerbel, Robert S., Dumont, Daniel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC152553/
https://ncbi.nlm.nih.gov/pubmed/12665569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.8.2658-2668.2003
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