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Grb2 Is a Negative Modulator of the Intrinsic Ras-GEF Activity of hSos1

hSos1 is a Ras guanine-nucleotide exchange factor. It was suggested that the carboxyl-terminal region of hSos1 down-regulates hSos1 functionality and that the intrinsic guanine-nucleotide exchange activity of this protein may be different before and after stimulation of tyrosine kinase receptors. Us...

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Detalhes bibliográficos
Main Authors: Zarich, Natasha, Oliva, José Luis, Martínez, Natalia, Jorge, Rocío, Ballester, Alicia, Gutiérrez-Eisman, Silvia, García-Vargas, Susana, Rojas, José M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1525251/
https://ncbi.nlm.nih.gov/pubmed/16760435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-12-1104
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