The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway

The mechanism by which YopP simultaneously inhibits mitogen-activated protein kinase (MAPK) and nuclear factor-κB pathways has been elusive. Ectopic expression of YopP inhibits the activity and ubiquitination of a complex consisting of overexpressed TGF-β-activated kinase 1 (TAK1) and its subunit TA...

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Bibliographische Detailangaben
Hauptverfasser: Thiefes, Axel, Wolf, Alexander, Doerrie, Anneke, A Grassl, Guntram, Matsumoto, Kunihiro, Autenrieth, Ingo, Bohn, Erwin, Sakurai, Hiroaki, Niedenthal, Rainer, Resch, Klaus, Kracht, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
Schlagworte:
Scientific Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1525148/
https://ncbi.nlm.nih.gov/pubmed/16845370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400754
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