Isolation of Three Mycobacterium ulcerans Strains Resistant to Rifampin after Experimental Chemotherapy of Mice

By use of a murine model for Buruli ulcer, Mycobacterium ulcerans was found to be susceptible to rifampin, with the MIC being 0.5 to 1 μg/ml. Three mutants were isolated after rifampin monotherapy. Two were resistant to rifampin at 8 μg/ml, and one was resistant to rifampin at 32 μg/ml. The mutants...

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Bibliografiske detaljer
Main Authors: Marsollier, Laurent, Honoré, Nadine, Legras, Pierre, Manceau, Anne Lise, Kouakou, Henri, Carbonnelle, Bernard, Cole, Stewart T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC152492/
https://ncbi.nlm.nih.gov/pubmed/12654651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.4.1228-1232.2003
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