Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery

BACKGROUND: Treatment of cells with the anti-cancer drug 5-fluorouracil (5-FU) causes DNA damage, which in turn affects cell proliferation and survival. Two stable wild-type TP53 5-FU-resistant cell lines, ContinB and ContinD, generated from the HCT116 colon cancer cell line, demonstrate moderate an...

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Bibliografiske detaljer
Main Authors: De Angelis, Paula M, Svendsrud, Debbie H, Kravik, Katherine L, Stokke, Trond
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2006
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1524802/
https://ncbi.nlm.nih.gov/pubmed/16709241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-5-20
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