Recombinant Environmental Libraries Provide Access to Microbial Diversity for Drug Discovery from Natural Products

To further explore possible avenues for accessing microbial biodiversity for drug discovery from natural products, we constructed and screened a 5,000-clone “shotgun” environmental DNA library by using an Escherichia coli-Streptomyces lividans shuttle cosmid vector and DNA inserts from microbes deri...

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Detalhes bibliográficos
Main Authors: Courtois, Sophie, Cappellano, Carmela M., Ball, Maria, Francou, Francois-Xavier, Normand, Philippe, Helynck, Gérard, Martinez, Asuncion, Kolvek, Steven J., Hopke, Joern, Osburne, Marcia S., August, Paul R., Nalin, Renaud, Guérineau, Michel, Jeannin, Pascale, Simonet, Pascal, Pernodet, Jean-Luc
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Physiology and Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC152451/
https://ncbi.nlm.nih.gov/pubmed/12513976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.69.1.49-55.2003
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