X-inactivation patch size in human female tissue confounds the assessment of tumor clonality

Most models of tumorigenesis assume that tumors are monoclonal in origin. This conclusion is based largely on studies using X chromosome-linked markers in females. One important factor, often ignored in such studies, is the distribution of X-inactivated cells in tissues. Because lyonization occurs e...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Novelli, Marco, Cossu, Antonio, Oukrif, Dahmane, Quaglia, Alberto, Lakhani, Sunil, Poulsom, Richard, Sasieni, Peter, Carta, Piera, Contini, Marcella, Pasca, Anna, Palmieri, Giuseppe, Bodmer, Walter, Tanda, Francesco, Wright, Nick
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The National Academy of Sciences 2003
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC152288/
https://ncbi.nlm.nih.gov/pubmed/12610207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0437825100
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