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An affibody in complex with a target protein: Structure and coupled folding

Combinatorial protein engineering provides powerful means for functional selection of novel binding proteins. One class of engineered binding proteins, denoted affibodies, is based on the three-helix scaffold of the Z domain derived from staphylococcal protein A. The Z(SPA-1) affibody has been selec...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wahlberg, Elisabet, Lendel, Christofer, Helgstrand, Magnus, Allard, Peter, Dincbas-Renqvist, Vildan, Hedqvist, Anders, Berglund, Helena, Nygren, Per-Åke, Härd, Torleif
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152267/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12594333/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0436086100
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