Mucosal Immunization with a Genetically Engineered Pertussis Toxin S1 Fragment-Cholera Toxin Subunit B Chimeric Protein

A chimeric protein consisting of a divalent pertussis toxin (PT) S1 fragment linked to the cholera toxin (Ctx) A(2)B fragment was constructed. The chimera induced a mucosal immunoglobulin A (IgA) and a serum IgG immune response to PT and CtxB in BALB/c mice following intranasal immunization. The imm...

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Detalhes bibliográficos
Main Authors: Lee, Song F., Halperin, Scott A., Salloum, Danny F., MacMillan, Ann, Morris, Annette
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2003
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC152103/
https://ncbi.nlm.nih.gov/pubmed/12654855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.4.2272-2275.2003
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