Virulence, Immunogenicity, and Protective Efficacy of Two Recombinant Mycobacterium bovis Bacillus Calmette-Guérin Strains Expressing the Antigen ESAT-6 from Mycobacterium tuberculosis

We constructed two recombinant Mycobacterium bovis BCG (rBCG) strains expressing ESAT-6 of Mycobacterium tuberculosis, named rBCG-1 and rBCG-2. rBCG-1 contained the ESAT-6 gene linked to BCG hsp60 and expressed a fusion protein, while rBCG-2, with a secretory sequence, could secret ESAT-6 into the c...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Bao, Lang, Chen, Wei, Zhang, Huidong, Wang, Xiaoying
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Microbial Immunity and Vaccines
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152063/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12654778/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.4.1656-1661.2003
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