Molecular genetic analysis of the cytochrome P450-debrisoquine hydroxylase locus and association with cancer susceptibility.

The cytochrome P450-dependent monooxygenases play a central role in the metabolism of chemical carcinogens. The action of these enzymes can lead to either carcinogen detoxication or activation. Differences in P450 expression in animal models give rise to large differences in susceptibility to chemic...

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Bibliographic Details
Main Authors: Smith, C A, Moss, J E, Gough, A C, Spurr, N K, Wolf, C R
Format: Artigo
Language:Inglês
Published: 1992
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1519624/
https://ncbi.nlm.nih.gov/pubmed/1486838
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