HIV protease inhibitors promote atherosclerotic lesion formation independent of dyslipidemia by increasing CD36-dependent cholesteryl ester accumulation in macrophages

Protease inhibitors decrease the viral load in HIV patients, however the patients develop hypertriglyceridemia, hypercholesterolemia, and atherosclerosis. It has been assumed that protease inhibitor–dependent increases in atherosclerosis are secondary to the dyslipidemia. Incubation of THP-1 cells o...

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Main Authors: Dressman, James, Kincer, Jeanie, Matveev, Sergey V., Guo, Ling, Greenberg, Richard N., Guerin, Theresa, Meade, David, Li, Xiang-An, Zhu, Weifei, Uittenbogaard, Annette, Wilson, Melinda E., Smart, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2003
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC151854/
https://ncbi.nlm.nih.gov/pubmed/12569165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316261
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