Osteoclasts are essential for TNF-α–mediated joint destruction

The detailed cellular and molecular mechanisms leading to joint destruction in rheumatoid arthritis, a disease driven by proinflammatory cytokines, are still unknown. To address the question of whether osteoclasts play a pivotal role in this process, transgenic mice that express human TNF (hTNFtg) a...

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Autori principali: Redlich, Kurt, Hayer, Silvia, Ricci, Romeo, David, Jean-Pierre, Tohidast-Akrad, Makiyeh, Kollias, George, Steiner, Günter, Smolen, Josef S., Wagner, Erwin F., Schett, Georg
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2002
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC151809/
https://ncbi.nlm.nih.gov/pubmed/12438440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15582
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