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Karyopherin-Mediated Nuclear Import of the Homing Endonuclease VMA1-Derived Endonuclease Is Required for Self-Propagation of the Coding Region

VMA1-derived endonuclease (VDE), a site-specific endonuclease in Saccharomyces cerevisiae, enters the nucleus to generate a double-strand break in the VDE-negative allelic locus, mediating the self-propagating gene conversion called homing. Although VDE is excluded from the nucleus in mitotic cells,...

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Udgivet i:Mol Cell Biol
Principais autores: Nagai, Yuri, Nogami, Satoru, Kumagai-Sano, Fumi, Ohya, Yoshikazu
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2003
Fag:
Nucleocytoplasmic Communication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151704/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12588991/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.5.1726-1736.2003
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