Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

Paclitaxel concentrations in the brain are very low after intravenous injection. Since paclitaxel is excluded from some tumors by p-glycoprotein (p-gp), the same mechanism may prevent entry into the brain. In vitro, paclitaxel transport was examined in capillaries from rat brains by confocal microsc...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Fellner, Stephan, Bauer, Björn, Miller, David S., Schaffrik, Martina, Fankhänel, Martina, Spruß, Thilo, Bernhardt, Günther, Graeff, Claudia, Färber, Lothar, Gschaidmeier, Harald, Buschauer, Armin, Fricker, Gert
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2002
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151606/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12417570/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI15451
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