An agonist-induced switch in G protein coupling of the gonadotropin-releasing hormone receptor regulates pulsatile neuropeptide secretion

The pulsatile secretion of gonadotropin-releasing hormone (GnRH) from normal and immortalized hypothalamic GnRH neurons is highly calcium-dependent and is stimulated by cAMP. It is also influenced by agonist activation of the endogenous GnRH receptor (GnRH-R), which couples to G(q/11) as indicated b...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Krsmanovic, Lazar Z., Mores, Nadia, Navarro, Carlos E., Arora, Krishan K., Catt, Kevin J.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2003
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151450/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12591945/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0535708100
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